增加表达组织纤溶酶原激活物和纤溶酶原激活物抑制剂2型与进步狗牙龈组织炎症。

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林德伯格P, B Kinnby Lecander我,朗NP, Matsson L

增加表达组织纤溶酶原激活物和纤溶酶原激活物抑制剂2型与进步狗牙龈组织炎症。

拱口腔医学杂志。2001年1月,46 (1):23-31。

PubMed ID

11163592 (在PubMed

]

文摘

尿激酶和组织类型纤溶酶原激活物物(u - PA和t - PA)丝氨酸蛋白酶,将纤溶酶原转化为物血纤维蛋白溶酶,蛋白质降解基质和激活金属蛋白酶。不平衡的由特定抑制剂(PAI - 1和PAI - 2)。当地生产的t - PA、PAI - 2最近被证明在人类牙龈组织。现在目标是调查和本地化生产的t - PA、PAI - 2在牙龈组织中狗的三个定义良好的牙周状况;临床健康齿龈、慢性牙龈炎和一个初始阶段ligature-induced附件的损失。在实验开始的齿龈显示明显的炎症的迹象。得到了临床健康齿龈后21天的激烈的口腔卫生。附件放置橡胶绷带引起的损失是脖子上的牙齿。活检是取自地区代表不同的条件和准备原位杂交和免疫组织化学。在临床健康齿龈t - PA mRNA和抗原表达瘦外层sulcular和交叉的上皮细胞。 No t--PA signals or staining were seen in connective tissue. Both mRNA signaling and immunostaining for t--PA were stronger in chronic gingivitis. In areas with loss of attachment, t--PA mRNA as well as antigen were found in the sulcular and junctional epithelia to a similar degree as in gingivitis. Occasionally the connective tissue was involved, especially in connection with vessels. PAI--2 mRNA was seen in a thin outer layer of the sulcular and junctional epithelia in clinically healthy gingiva, but no signals were seen in connective tissue. PAI--2 antigen was found primarily in the outer layer of the sulcular and junctional epithelia. Some cells in the connective tissue were stained. In gingivitis, PAI--2 signals were mainly found in the same locations, but more intense and extending towards the connective tissue. Immunostaining was seen in the outer half of the sulcular and junctional epithelia as well as in the upper part of the connective tissue, close to the sulcular epithelium. In sites with loss of attachment, PAI--2 mRNA was found throughout the sulcular and junctional epithelia, as was the antigen, which stained intensely. No PAI--2 mRNA was seen in connective tissue; the antigen was found scattered, especially near vessels. This study shows that the expression of both t--PA and PAI--2 increases with experimental gingival inflammation in the dog, and furthermore, the two techniques demonstrate a strong correlation between the topographical distribution of the site of protein synthesis and the tissue location of the antigens for both t--PA and PAI--2. The distribution correlates well with previous findings in humans.

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药物靶点

药物	目标	类	生物	药理作用	行动
Tenecteplase	纤溶酶原激活物抑制剂1	蛋白质	人类	未知的	不可用	细节