体内糖皮质激素受体信使rna的调制吸入丙酸在支气管粘膜和血液淋巴细胞与轻度哮喘受试者。
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Andersson O,卡塞尔TN, Gronneberg R, Bronnegard M,北国Stierna P M
体内糖皮质激素受体信使rna的调制吸入丙酸在支气管粘膜和血液淋巴细胞与轻度哮喘受试者。
J过敏Immunol。1999年4月,103 (4):595 - 600。
- PubMed ID
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10200007 (在PubMed]
- 文摘
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背景:体内糖皮质激素糖皮质激素受体(GR)的监管提供了一种方法的目标细胞的调节灵敏度。目的:我们试图确定GR mRNA表达的体内调制丙酸(FP)科目有轻度哮喘。方法:10过敏性哮喘受试者接受《外交政策》250 microg 4周每日两次。之前和之后的治疗,患者进行纤维支气管镜检查和支气管活检取样测量的静脉血GR mRNA水平。解决杂交试验被用于定量分析的GR mRNA。此外,24小时尿皮质醇分泌和促肾上腺皮质激素与FP进行测试之前和之后的治疗。结果:高个人间GR mRNA表达的变化。然而,我们发现的GR mRNA水平显著降低支气管活检标本FP治疗后(36.6 + / - 23.1和25.0 + / - 10.9阿莫勒GR mRNA / microg RNA,分别;P < . 01)。在外周血淋巴细胞的差别更引人注目的对这些同源GR的配体是记录(30.3 + / - 26.5和8.8 + / - 5阿莫勒GR mRNA / microg RNA,分别; P <.001), possibly reflecting differences in glucocorticoid sensitivity between tissues. A small but significant reduction of the 24-hour urinary cortisol excretion was observed (233 +/- 109 and 157 +/- 66 nmol/L, respectively; P <.01), whereas the feedback regulation of glucocorticoid synthesis by means of the hypothalamic-pituitary-adrenal axis as assessed by the adrenocorticotropic hormone test remained normal after treatment with FP. CONCLUSION: The results in this study confirm the potency of the inhaled corticosteroid FP and provide evidence for a considerable tissue-specific interindividual variation in the expression of the GR.