的角色dornase阿尔法治疗囊性纤维化。

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克莱默瓦,Bosso农协

的角色dornase阿尔法治疗囊性纤维化。

安Pharmacother。1996年6月,30 (6):656 - 61。

PubMed ID
8792953 (在PubMed
]
文摘

目的:回顾目前的效用和适当的角色dornase阿尔法(重组人类DNase或rhDNase),已被批准用于囊性纤维化。相关的几个方面解决这些问题包括药物的作用机制、政府和剂量,临床安全性和有效性。我们也严格检查代理在cysti纤维化的治疗中的作用和考虑争议涉及其使用。数据来源:MEDLINE搜索进行了识别相关的文献,包括评论文章和临床试验。研究选择:研究的有效性和安全性dornase阿尔法在囊性纤维化患者。数据提取:发表的结果,提出了前瞻性随机试验和评论。生产数据合成:粘性呼吸道分泌物是囊性纤维化的特征现象,导致各种症状。Dornase阿尔法目标这个症状和减少这些分泌物的粘度。临床试验显示一个小但显著改善在1秒用力呼气量和最大肺活量。增强患者的呼吸困难和生活质量之间的各种试验,很少有研究指出没有显著改善。 Adverse reactions are minimal and did not result in any patient withdrawals from the trials. A positive impact on infection rates, length of hospitalization, and need for intravenous antibiotic therapy was noted in one trial. However, reports of similar results have not yet been published, and thus the clinical significance or impact of this phenomenon is not fully understood. Moreover, results of more long-term use and in patients whose conditions are less stable have yet to undergo the scrutiny of peer/editorial review. Administration of the drug, which must be maintained continuously, is relatively expensive. CONCLUSIONS: Dornase alfa appears to produce small but sustained improvements in lung function in patients with cystic fibrosis. It may also slow the progression of pulmonary disease. Infection rates appear to be reduced, which may well have important long-term consequences. However, evidence to date has not clarified the most appropriate use of dornase alfa in the treatment of cystic fibrosis. Whether quality of life is affected in a meaningful and measurable way is yet to be clarified. A trial of the drug in patients with cystic fibrosis who have obvious lung disease is reasonable, but continued treatment should be based on clear clinical response. Therefore, questions about the drug's exact role in the overall management of cystic fibrosis remain to be answered. Although benefits received may not prove to be cost-effective, long-term effects on disease progression may well justify use of this agent.

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药物
药物靶点
药物 目标 类 生物 药理作用 行动
Dornase阿尔法 DNA 核苷酸 人类
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