5-HT1B受体,alpha2A / 2 c -,在较小程度上,alpha1-adrenoceptors调解颈外动脉血管收缩在vagosympathectomised狗麦角胺。

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瓦尔迪维亚低频百夫长D Arulmani U, Saxena公关,Villalon厘米

5-HT1B受体,alpha2A / 2 c -,在较小程度上,alpha1-adrenoceptors调解颈外动脉血管收缩在vagosympathectomised狗麦角胺。

Naunyn Schmiedebergs拱杂志。2004年7月,370 (1):46-53。Epub 2004年6月29日。

PubMed ID

15224175 (在PubMed

]

文摘

它曾被建议麦角胺产生颈外动脉血管收缩vagosympathectomised狗通过5-HT1B / 1 d受体和alpha2-adrenoceptors。目前研究重新分析这个建议通过使用更多的选择性拮抗剂单独和组合。52犀牛狗准备超声测量颈外动脉的血液流动。动物们被分成13组(n = 4)接受静脉输液丸注入,生理盐水(0.3毫升/公斤;控制)或拮抗剂SB224289 (300 microg /公斤;5-HT1B), BRL15572 (300 microg /公斤;5-HT1D), rauwolscine (300 microg /公斤;alpha2), SB224289 + BRL15572 (300 microg /公斤),SB224289 + rauwolscine (300 microg /公斤),BRL15572 + rauwolscine (300 microg /公斤),rauwolscine (300 microg /公斤)+哌唑嗪(100 microg /公斤;α1),SB224289 (300 microg /公斤)+哌唑嗪(100 microg /公斤),SB224289 (300 microg /公斤)+ rauwolscine (300 microg /公斤)+哌唑嗪(100 microg /公斤),SB224289 (300 microg /公斤)+哌唑嗪(100 microg /公斤)+ BRL44408 (1000 microg /公斤;alpha2A), SB224289 (300 microg /公斤)+哌唑嗪(100 microg /公斤)+ imiloxan (1000 microg /公斤; alpha2B), or SB224289 (300 microg/kg) + prazosin (100 microg/kg) + MK912 (300 microg/kg; alpha2C). Each group received consecutive 1-min intracarotid infusions of ergotamine (0.56, 1, 1.8, 3.1, 5.6, 10 and 18 microg/min), following a cumulative schedule. In saline-pretreated animals, ergotamine induced dose-dependent decreases in external carotid blood flow without affecting arterial blood pressure or heart rate. These control responses were: unaffected by SB224289, BRL15572, rauwolscine or the combinations of SB224289 + BRL15572, BRL15572 + rauwolscine, rauwolscine + prazosin, SB224289 + prazosin, or SB224289 + prazosin + imiloxan; slightly blocked by SB224289 + rauwolscine; and markedly blocked by SB224289 + rauwolscine + prazosin, SB224289 + prazosin + BRL44408 or SB224289 + prazosin + MK912. Thus, the cranio-selective vasoconstriction elicited by ergotamine in dogs is predominantly mediated by 5-HT1B receptors as well as alpha2A/2C-adrenoceptor subtypes and, to a lesser extent, by alpha1-adrenoceptors.

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药物靶点

药物	目标	类	生物	药理作用	行动
麦角胺	5 -羟色胺受体1 b	蛋白质	人类	是的	受体激动剂	细节