beta1拮抗剂和beta2兴奋剂,塞,恢复受损的内皮依赖和独立的反应和减少TNFalpha与II型糖尿病鼠。
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Hayashi T,朱丽叶PA, Miyazaki-Akita Funami J, Matsui-Hirai H, Fukatsu,井口
beta1拮抗剂和beta2兴奋剂,塞,恢复受损的内皮依赖和独立的反应和减少TNFalpha与II型糖尿病鼠。
生命科学。2007年1月16日,80 (6):592 - 9。Epub 2006 12月1。
- PubMed ID
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17141277 (在PubMed]
- 文摘
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β拮抗剂在糖尿病血管病变的影响是有争议的。我们研究了盐酸塞的影响,beta1拮抗剂和温和beta2兴奋剂,病变和功能在II型男性大冢Long-Evans德岛糖尿病大鼠脂肪(OLETF)。OLETF大鼠喂养常规食物有或没有阿替洛尔(25毫克/公斤/天)或塞(100毫克/公斤/天)治疗(DM组,没有治疗;集团DM-a阿替洛尔治疗;集团DM-c塞治疗),治疗持续了31天。勒托,另外,normoglycemic控制老鼠准备组c . 3天,右颈内动脉的内皮细胞被气球受伤,和老鼠评估球囊损伤后4周。血糖和血脂水平在整个治疗期间保持不变。观察内膜的增厚的DM和DM-a组颈动脉;然而,观察小增厚在DM-c老鼠。Acetylcholine-induced一氧化氮放松在提高动脉DM-c老鼠相比,DM和DM-a老鼠(最大放松DM 30.8 + / - -4.5, DM-a 37.4 + / - -3.9, DM-c 48.8 + / - -4.6%, * P < 0.05与DM DM-c老鼠)。 Tone-related basal NO release and acetylcholine-induced NO-dependent relaxation in the arteries and plasma NO(x) (sum of NO(2)(-) and NO(3)(-)) were greater in DM-c and C groups than in DM and DM-a groups. The serum TNFalpha levels did not increase in DM-c rats compared with those of the DM or DM-a groups, and were comparable with those of group C. CONCLUSION: In conclusion, Celiprolol improves endothelial function in the arteries of OLETF rats, and further restore it 4 weeks after endothelial denudation in the arteries of OLETF rats. NO and O(2)(-) may have a role in the important underlying mechanisms by reducing the TNFalpha levels.