类固醇代谢细胞色素P450 2 c9变体。

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北川Uno T, Nakano R, R,冈田克也M, Kanamaru K,竹中平藏,Uno Y, Imaishi H

类固醇代谢细胞色素P450 2 c9变体。

Biopharm药物Dispos。2018年9月,39 (8):371 - 377。doi: 10.1002 / bdd.2153。

PubMed ID

30098040 (在PubMed

]

文摘

CYP2C9是人类微粒体细胞色素P450c (CYP)。CYP2C9水平变化和活动可以归因于这种基因的多态性。野生型CYP2C9和十个突变体与NADPH-cytochrome P450还原酶在大肠杆菌中的。羟化酶活动对类固醇检查。CYP2C9.2、CYP2C9.3 CYP2C9.4、CYP2C9.16 CYP2C9.28,睾丸激素6 beta-hydroxylation CYP2C9.48和CYP2C9.52高于CYP2C9.1。比CYP2C9.1 CYP2C9.4显示更高的孕激素6 beta-hydroxylation活动。CYP2C9.28 CYP2C9.48显示,孕酮11 alpha-hydroxylation活动比CYP2C9.1高。比CYP2C9.1 CYP2C9.48显示更高的孕激素16 alpha-hydroxylation活动。CYP2C9.2、CYP2C9.3 CYP2C9.16和CYP2C9.30比CYP2C9.1更高的雌激素酮16 alpha-hydroxylation活动。比CYP2C9.1 CYP2C9.3有更高的雌激素酮11 alpha-hydroxylation活动。 CYP2C9.39 and CYP2C9.57 showed similar activities to CYP2C9.1. These results indicate that the substrate specificity of CYP2C9.39 and CYP2C9.57 was not changed, but CYP2C9.2, CYP2C9.3, CYP2C9.4, CYP2C9.16, CYP2C9.28, CYP2C9.30, CYP2C9.48 and CYP2C9.52 showed different hydroxylation activities toward steroids compared with CYP2C9.1.

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药物酶

药物	酶	类	生物	药理作用	行动
雌激素酮	细胞色素P450 2 c9	蛋白质	人类	未知的	底物	细节