脱氢表雄酮(DHEA)补充健康的老年人的认知功能。

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埃文斯Grimley J, Malouf R,于佩尔F,范Niekerk JK

脱氢表雄酮(DHEA)补充健康的老年人的认知功能。

科克伦数据库系统启2006年10月18日;(4):CD006221。

PubMed ID
17054283 (在PubMed
]
文摘

背景:针对有利影响的理论可能性脱氢表雄酮和脱氢表雄酮在制动与年龄有关的认知功能恶化,我们回顾了研究在这个领域。目的:确定管理脱氢表雄酮,或其硫酸脱氢表雄酮,改善认知功能或降低,下降的速度正常老年人的认知功能。搜索策略:确定了试验的最后更新搜索Cochrane痴呆和认知改善小组的专业注册使用脱氢表雄酮*,2005年10月10日,普拉睾酮脱氢表雄酮*。除了MEDLINE和EMBASE, PsycINFO和CINAHL找搜索试验志愿者没有或小内存的抱怨。相关期刊、个人通讯和会议摘要搜索随机对照试验调查脱氢表雄酮/ S的影响在老年人的认知。选择标准:所有随机安慰剂对照临床试验登记人50岁以上没有痴呆和脱氢表雄酮/ S在任何剂量管理了超过一天被认为是列入审查。数据收集和分析:指定结果独立提取数据由两个评论家(JGE和RM)和交叉检查。任何不符点进行了讨论和解决。没有数据池是由于缺乏相关统计数据的可用性。主要结果:只有三个研究结果提供足够的与这些相应平行的组织数据。 Barnhart 1999 enrolled perimenopausal women with complaints of decreased well-being and, using three cognitive measures, found no significant effect of DHEA compared with placebo at 3 months. Wolf 1998b enrolled 75 healthy volunteers (37 women and 38 men aged 59-81) in a study of the effect of DHEA supplements on cognitive impairment induced by stress; after two weeks of treatment, placebo group performance deteriorated significantly on a test of selective attention following a psychosocial stressor (p<0.05), while deterioration was not evident in the DHEA group (p=0.85). However, when compared with placebo, DHEA was associated with a significant impairment on a visual memory recall test (p<0.01) following the stressor. No significant effects were found on a third cognitive task. Effects were not found on tasks when administered in the absence of a stressor. van Niekerk 2001 found no effect on cognitive function in 46 men aged 62-76 from three months of DHEA supplementation. DHEA supplements were well tolerated and without significant adverse effects apart from the reduced performance in the visual memory recall test observed in one trial. AUTHORS' CONCLUSIONS: What little evidence there is from controlled trials does not support a beneficial effect of DHEA supplementation on cognitive function of non demented middle-aged or elderly people. There is no consistent evidence from the controlled trials that DHEA produces any adverse effects. In view of growing public enthusiasm for DHEA supplementation, particularly in the USA, and the theoretical possibility of long-term neuroprotective effects of DHEA/S, there is a need for further high quality trials in which the duration of DHEA treatment is longer than one year, and the number of participants is large enough to provide adequate statistical power.

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