普瑞巴林的功效作为术前用药法阴道子宫切除术的术后镇痛。
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中收取Rajappa GC,年代,Bevanaguddaiah Y, Anadaswamy TC
普瑞巴林的功效作为术前用药法阴道子宫切除术的术后镇痛。
Anesth疼痛医学。2016年5月14日,6 (3):e34591。doi: 10.5812 / aapm.34591。eCollection 2016年6月。
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27642577 (在PubMed]
- 文摘
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背景:普瑞巴林的结构模拟伽马氨基丁酸(GABA),证明是有效的治疗神经性疼痛的几种类型,切口损伤,炎症损伤。目的:本研究的目的是比较两个剂量的疗效(75毫克或150毫克)的普瑞巴林政府的安慰剂在脊髓麻醉下接受子宫切除术的患者术后镇痛。患者和方法:在135例患者进行了一项随机、安慰剂对照试验进行阴道子宫切除术在脊髓麻醉。45岁患者的病人被分为三组:每组0,安慰剂;组1,75毫克普瑞巴林;和组2、150毫克普瑞巴林;每个治疗管理手术前一个小时。拉姆齐镇静规模(RSS)用于术前评估和视觉模拟量表(血管)是用来确定第一术后疼痛在休息和咳嗽。救援的时间要求在第一次术后镇痛药天也被评估。结果:RSS分数显著高于组1和2相比对照组(P < 0.001)。 Postoperative VAS scores for pain both at rest and on cough were significantly reduced in groups 1 and 2 (P < 0.001). Rescue analgesic consumption decreased significantly in groups 1 and 2 (P < 0.001). The time at which rescue analgesia was administered (first dose) was 4.45 hours in group 0, 10.86 hours in group 1, and 16.82 hours in group 2 (P < 0.001). CONCLUSIONS: Pregabalin administered as premedication provided significant postoperative pain relief and decreased the requirement of other parenteral analgesics. Pregabalin doses of 150 mg had a better analgesic profile, but the advantages of their use may be limited by side effects such as dizziness. Thus, it is concluded that pregabalin doses of 75 mg may be the optimal pre-emptive dose.
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