网状的血小板和不羁COX-1和cox - 2降低阿司匹林的抗血小板作用。

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Guthikonda年代,列弗EI, Patel R, DeLao T, Bergeron半岛,东摩根富林明,克雷曼NS

网状的血小板和不羁COX-1和cox - 2降低阿司匹林的抗血小板作用。

J Thromb Haemost。2007年3月,5 (3):490 - 6。

PubMed ID

17319904 (在PubMed

]

文摘

背景:在阿司匹林抗血小板的影响变化的机制尚不清楚。不成熟(网状)血小板可能调节阿司匹林的抗血小板作用通过不羁环氧合酶(COX) 1和COX - 2。目的:评估网状血小板的作用在阿司匹林的抗血小板作用。方法:60名健康志愿者血小板研究执行之前和之后24小时一个325毫克剂量的阿司匹林。血小板研究包括光传输aggregometry;P-selectin和整合素α(IIb)β(3)表达和血清凝血恶烷B (2) (TxB(2))的水平。网状的血小板和血小板cox - 2表达使用流式细胞仪测定。结果:受试者分为tertiles基于网状的百分比在全血血小板。基线血小板聚集到1 microg毫升(1)胶原蛋白,和postaspirin聚合到5 microm 20 microm ADP和胶原蛋白,是更大的上部比下部tertile网状的血小板。刺激P-selectin和整合素α(IIb)β(3)表达式也高于上层tertile前后阿司匹林。 Platelet COX-2 expression was detected in 12 +/- 7% (n = 10) of platelets in the upper tertile, and in 7 +/- 3% (n = 12) of platelets in the lower two tertiles (P = 0.03). Postaspirin serum TxB(2) levels were higher in the upper (5.5 +/- 4 ng mL(-1)) than in the lower tertile (3.2 +/- 2.5 ng mL(-1), P = 0.03), and decreased even further with ex vivo additional COX-1 and COX-2 inhibition. The incidence of aspirin resistance (>or= 70% platelet aggregation to 5 microm ADP) was significantly higher in the upper tertile (45%) than in the lower tertile (5%, P < 0.0001). CONCLUSIONS: Reticulated platelets are associated with diminished antiplatelet effects of aspirin and increased aspirin resistance, possibly because of increased reactivity, and uninhibited COX-1 and COX-2 activity.

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药物靶点

药物	目标	类	生物	药理作用	行动
乙酰水杨酸	前列腺素合成酶1 G / H	蛋白质	人类	是的	抑制剂	细节