PPADS ATP拮抗剂,变弱的影响一个中等强度的声音在耳蜗力学。

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PPADS ATP拮抗剂,变弱的影响一个中等强度的声音在耳蜗力学。

听到2001年》156年6月,(1 - 2):10 - 6。

PubMed ID

11377878 (在PubMed

]

文摘

越来越多的关注正在给神经递质和其他信号物质的作用在耳蜗损伤引起的强烈的声音。三磷酸腺苷(ATP)的一个例子是一个假定的神经递质,可能改变耳蜗力学在声音暴露。本研究的目的是测试假设内源性细胞外ATP的生成作用的变化引起的耳蜗力学温和接触强烈的声音。豚鼠暴露在:(1)perilymphatic pyridoxal-phosphate-6-azophenyl-2管理',4 ' -disulphonic酸(PPADS, 1毫米),ATP拮抗剂;(2)一个中等强度的声音(6 kHz的语气,95分贝,15分钟);或(3)PPADS和声音的结合。影响产品立方畸变耳声排放(DPOAEs;2 f1-f2)监控使用三组同等水平的初选(f1 = 9.25 kHz, f2 = 10.8 kHz, 2 f1-f2 = 7.7千赫;f1 = 7.2 kHz, f2 = 8.4 kHz, 2 f1-f2 = 6赫兹;f1 = 5.55 kHz, f2 = 6.5 kHz, 2 f1-f2 = 4.6 kHz)。 PPADS alone had no effect on the cubic DPOAEs monitored. The intense sound alone suppressed all three cubic DPOAEs. The combination of PPADS with the intense sound induced a suppression of the cubic DPOAEs that was equal to or greater than induced by the intense sound alone at f2=10.8 kHz but was equal to or less than induced by the intense sound at f2=8.4 and 6.5 kHz. After washing the PPADS out of the cochlea with artificial perilymph, all three cubic DPOAEs were suppressed less in the PPADS with intense sound treatment group than in the intense sound alone group. The PPADS appeared to provide protection from the intense sound. Results are consistent with the hypothesis that extracellular ATP is involved in the changes in cochlear mechanics induced by moderately intense sound exposure.

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药物靶点

药物	目标	类	生物	药理作用	行动
磷酸吡哆醛	Sphingosine-1-phosphate裂合酶1	蛋白质	人类	未知的	代数余子式	细节