Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells.
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Derynck R, Jarrett JA, Chen EY, Eaton DH, Bell JR, Assoian RK, Roberts AB, Sporn MB, Goeddel DV
Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells.
Nature. 1985 Aug 22-28;316(6030):701-5.
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3861940 [View in PubMed]
- Abstract
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The partial amino-acid sequence of purified human transforming growth factor-beta (TGF-beta) was used to identify a series of cDNA clones encoding the protein. The cDNA sequence indicates that the 112-amino acid monomeric form of the natural TGF-beta homodimer is derived proteolytically from a much longer precursor polypeptide which may be secreted. TGF-beta messenger RNA is synthesized in various normal and transformed cells.