Cholestanes

Name
Cholestanes
Accession Number
DBCAT000308
Description

Derivatives of the saturated steroid cholestane with methyl groups at C-18 and C-19 and an iso-octyl side chain at C-17.

Drugs
Drug Drug Description
Calcitriol An active metabolite of vitamin D that is used to treat hyperparathyroidism and is also used in dialysis patients to combat hypocalcemia.
Alfacalcidol A vitamin D analogue used for the management of hypocalcemia, secondary hyperparathyroidism, and osteodystrophy in patients with chronic renal failure, as well as some types of rickets and osteomalacia.
Fusidic acid A topical antibacterial agent used to prevent and treat mild to moderate skin infections caused by susceptible bacteria.
Soy sterol Not Annotated
Cholecalciferol A form of Vitamin D used in the treatment of specific medical conditions such as refractory rickets, hypoparathyroidism, and familial hypophosphatemia, as well as osteoporosis and chronic kidney disease.
Paricalcitol 维生素D模拟用于治疗恶性parathyroidism associated with stage 3 or greater chronic kidney disease.
Cholesterol The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
1alpha,24S-Dihydroxyvitamin D2 Investigated for use/treatment in parathyroid disorders.
Doxercalciferol A synthetic vitamin D2 analog used to treat secondary hyperparathyroidism in patients with chronic kidney disease with or without therapy of dialysis.
Cholesteryl chloride Cholesteryl chloride, also known as 3-chlorocholest-5-ene, is an organochloride derivative of cholesterol. It is presented as a liquid crystal that forms clockwise liquid crystals.
Calcifediol An active metabolite of vitamin D used to treat hyperparathyroidism as well as to combat hypocalcemia in dialysis patients.
Dihydrotachysterol A synthetic analog of vitamin D that does not require renal activation like vitamin D2 or Vitamin D3.
Cholesterol sulfate Component of human seminal plasma & spermatozoa.
Cholesteryl Linoleate Not Available
Calcipotriol 局部合成维生素D2导数中使用the treatment of plaque psoriasis.
Lexacalcitol Lexacalcitol is a solid. This compound belongs to the vitamin D and derivatives class of chemicals. These are compounds containing a secosteroid backbone, usually secoergostane or secocholestane. It is known...
Lanosterol Not Available
Ergosterol A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS...
Seocalcitol Not Available
20-hydroxycholesterol Not Available
25-Hydroxycholesterol Not Available
7beta-hydroxycholesterol Not Available
Inecalcitol Investigated for use/treatment in prostate cancer, psoriasis and hyperparathyroidism.
Becocalcidiol For topical treatment of psoriasis and psoriatic disorders.
Olesoxime Investigated for use/treatment in neurologic disorders.
Caprospinol Alzheimer's Disease
Smilagenin Investigated for use/treatment in alzheimer's disease, parkinson's disease and other neurodegenerative diseases.
Elocalcitol Investigated for use/treatment in benign prostatic hyperplasia, urinary incontinence, prostate disorders, and infertility.
Maxacalcitol Not Annotated
Squalamine Investigated for use/treatment in ovarian cancer, lung cancer, and macular degeneration.
1alpha-Hydroxyvitamin D5 1alpha-Hydroxyvitamin D5 (CARD-024) has been used in trials studying the treatment of Drug Safety and Heart; Disease, Activity.
Iodine (131I) norcholesterol A radioiodine-labeled cholesterol analogue that accumulates in areas where steroid hormones are produced and is used in certain diagnostic procedures.
Tacalcitol A vitamin D analog indicated in the treatment of mild to moderate plaque psoriasis.
beta-Sitosterol Active fraction of Solanum trilobatum; reduces side-effects of radiation-induced toxicity.
24-Homo-1,25-dihydroxyvitamin D3 24-Homo-1,25-dihydroxyvitamin D3 is a novel vitamin D analogue.
Previtamin D(3) Not Annotated
Ruscogenin An anti-inflammatory steroid used in combination with local anesthetics for the treatment of hemorrhoids and for local anesthesia.
Sarsagenin Not Annotated
20-Hydroxyecdysone Not Annotated
Drugs & Drug Targets
Drug Target Type
Calcitriol Vitamin D3 receptor target
Calcitriol 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial enzyme
Calcitriol Cytochrome P450 3A4 enzyme
Calcitriol Homeobox protein Hox-A10 target
Calcitriol Vitamin D-binding protein carrier
Alfacalcidol Vitamin D-binding protein carrier
Alfacalcidol Vitamin D3 receptor target
Alfacalcidol 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial target
Alfacalcidol Retinoic acid receptor RXR-alpha target
Alfacalcidol Alpha globin carrier
Fusidic acid Chloramphenicol acetyltransferase 3 target
Fusidic acid Chloramphenicol acetyltransferase target
Fusidic acid Bile salt export pump transporter
Fusidic acid Canalicular multispecific organic anion transporter 1 transporter
Fusidic acid Elongation factor G target
Fusidic acid Cytochrome P450 2D6 enzyme
Fusidic acid Cytochrome P450 3A4 enzyme
Fusidic acid UDP-glucuronosyltransferase 1-1 enzyme
Fusidic acid ATP-binding cassette sub-family G member 2 transporter
Fusidic acid Solute carrier organic anion transporter family member 1B1 transporter
Cholecalciferol Vitamin D-binding protein carrier
Cholecalciferol Cholesterol side-chain cleavage enzyme, mitochondrial enzyme
Cholecalciferol Vitamin D 25-hydroxylase enzyme
Cholecalciferol Sterol 26-hydroxylase, mitochondrial enzyme
Cholecalciferol Cytochrome P450 2J2 enzyme
Cholecalciferol Cytochrome P450 3A4 enzyme
Cholecalciferol Vitamin D3 receptor target
Cholecalciferol Cytochrome P450 1A1 enzyme
Cholecalciferol Cytochrome P450 2C8 enzyme
Paricalcitol Vitamin D3 receptor target
Paricalcitol 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial enzyme
Paricalcitol Cytochrome P450 3A4 enzyme
Paricalcitol UDP-glucuronosyltransferase 1-4 enzyme
Cholesterol Nuclear receptor ROR-alpha target
Cholesterol P-glycoprotein 1 transporter
Cholesterol ATP-binding cassette sub-family G member 2 transporter
Cholesterol Nuclear receptor subfamily 1 group I member 3 target
Cholesterol Vitamin D3 receptor target
Cholesterol C-type lectin domain family 4 member E target
Doxercalciferol Sterol 26-hydroxylase, mitochondrial enzyme
Doxercalciferol Vitamin D3 receptor target
Calcifediol 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial enzyme
Calcifediol Vitamin D3 receptor target
Calcifediol 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial enzyme
Dihydrotachysterol Vitamin D3 receptor target
Cholesterol sulfate Nuclear receptor ROR-alpha target
Cholesteryl Linoleate Lipase 3 target
Calcipotriol Vitamin D3 receptor target
Calcipotriol Myeloperoxidase enzyme
Calcipotriol 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial enzyme
Lexacalcitol Vitamin D3 receptor target
Lanosterol Lanosterol synthase target
Seocalcitol Vitamin D3 receptor target
Inecalcitol Vitamin D3 receptor target
Becocalcidiol Mediator of RNA polymerase II transcription subunit 1 target
Becocalcidiol Vitamin D3 receptor target
Elocalcitol Vitamin D3 receptor target