NAV

Octisalate

Identification

Brand Names
Eucerin, Meijer, Sumadan Wash
Generic Name
Octisalate
DrugBank Accession Number
DB11062
Background

Also known as Ethylhexyl Salicylate. Octyl salicylate is an oil soluble chemical sunscreen agent that absorbs UVB radiation. It does not protect against UVA. Octyl salicylate is used to augment the UVB protection in a sunscreen. Salicylates are weak UVB absorbers and they are generally used in combination with other UV filters. Octyl salicylate appears to have a good safety profile. It covers wavelength in the range 295-315 nm, peak at 307-310 nm.

It is an ester of salicylic acid and 2-ethylhexanol. The salicylate portion of the molecule absorbs ultraviolet light to protect skin from the harmful effects of exposure to sunlight, while the ethylhexanol portion functions as an emollient.

Type
Small Molecule
Groups
Approved, Investigational
Structure
 3D
Similar Structures
Weight
Average: 250.3334
Monoisotopic: 250.15689457
Chemical Formula
C15H22O3
Synonyms
  • 2-Ethylhexyl 2-hydroxybenzoate
  • 2-Ethylhexyl salicylate
  • Octisalate
  • Octyl salicylate
External IDs
  • USAF DO-11

Pharmacology

Indication

Ingredient in sunscreens for protection against damage effects of sun light, provides protection from sunburns, aging and skin cancer.

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Associated Conditions
Contraindications & Blackbox Warnings
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Pharmacodynamics

Data not found.

Mechanism of action

Chemical sunscreen, it acts through absorption of UVB light and not UVA.

Absorption

Intended for local use only, no systemic absorption.

Volume of distribution

Intended for local use only, no systemic absorption.

Protein binding

Intended for local use only, no systemic absorption.

Metabolism

Intended for local use only, no systemic absorption.

Route of elimination

Intended for local use only, no systemic absorption.

Half-life

Intended for local use only, no systemic absorption.

Clearance

Intended for local use only, no systemic absorption.

Adverse Effects
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Toxicity

LD50, (oral, rat): > 5000 mg/Kg. LD50 (dermal, rabbit): > 5000 mg/Kg.

Pathways
Not Available
Pharmacogenomic Effects/ADRsBrowse all" title="" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
Not Available

Interactions

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This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

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Active Moieties
Name Kind UNII CAS InChI Key
Salicylic acid unknown O414PZ4LPZ 69-72-7 YGSDEFSMJLZEOE-UHFFFAOYSA-N
Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image
(Re)Setting Refreshing Mist SPF 40 Octisalate(4.9 g/100mL)+Avobenzone(2.9 g/100mL)+Homosalate(9.8 g/100mL)+Octocrylene(9.5 g/100mL) Spray Topical Supergoop, LLC 2022-01-05 Not applicable US flag
01 Balancing Foundation SPF 15 Octisalate(2.5 mg/0.5mL)+Octinoxate(3.75 mg/0.5mL)+Titanium dioxide(1.45 mg/0.5mL) Emulsion Topical The Body Shop, Wake Forest 2009-09-06 2017-10-05 US flag
02 Balancing Foundation SPF 15 Octisalate(2.5 mg/0.5mL)+Octinoxate(3.75 mg/0.5mL)+Titanium dioxide(1.45 mg/0.5mL) Emulsion Topical The Body Shop, Wake Forest 2009-09-06 2017-10-05 US flag
02 Cushion Spf45 Sunscreen Octisalate(5 g/100mL)+Octinoxate(5 g/100mL)+Octocrylene(2.5 g/100mL)+Titanium dioxide(13.5 g/100mL)+Zinc oxide(8 g/100mL) Liquid Topical COIZ CO LTD 2019-06-30 Not applicable US flag
03 Balancing Foundation SPF 15 Octisalate(2.5 mg/0.5mL)+Octinoxate(3.75 mg/0.5mL)+Titanium dioxide(1.45 mg/0.5mL) Emulsion Topical The Body Shop, Wake Forest 2009-09-06 2017-10-05 US flag
04 Balancing Foundation SPF 15 Octisalate(2.5 mg/0.5mL)+Octinoxate(3.75 mg/0.5mL)+Titanium dioxide(1.45 mg/0.5mL) Emulsion Topical The Body Shop, Wake Forest 2009-09-06 2017-10-05 US flag
05 Balancing Foundation SPF 15 Octisalate(2.5 mg/0.5mL)+Octinoxate(3.75 mg/0.5mL)+Titanium dioxide(1.45 mg/0.5mL) Emulsion Topical The Body Shop, Wake Forest 2009-09-06 2017-10-05 US flag
06 Balancing Foundation SPF 15 Octisalate(2.5 mg/0.5mL)+Octinoxate(3.75 mg/0.5mL)+Titanium dioxide(1.45 mg/0.5mL) Emulsion Topical The Body Shop, Wake Forest 2009-09-06 2017-10-05 US flag
07 Balancing Foundation SPF 15 Octisalate(2.5 mg/0.5mL)+Octinoxate(3.75 mg/0.5mL)+Titanium dioxide(1.45 mg/0.5mL) Emulsion Topical The Body Shop, Wake Forest 2009-09-06 2017-10-05 US flag
08 Balancing Foundation SPF 15 Octisalate(2.5 mg/0.5mL)+Octinoxate(3.75 mg/0.5mL)+Titanium dioxide(1.45 mg/0.5mL) Emulsion Topical The Body Shop, Wake Forest 2009-09-06 2017-10-05 US flag
Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image
4362 First Aid Kit Octisalate(5 g/100mL)+Ammonia(0.045 g/0.3mL)+Avobenzone(1 g/100mL)+Bacitracin zinc(400 [iU]/1g)+Benzalkonium chloride(1.3 mg/1mL)+Ethanol(0.5 mL/1mL)+Homosalate(5 g/100mL)+Hydrocortisone acetate(1 g/100g)+Isopropyl alcohol(0.7 mL/1mL)+Lidocaine hydrochloride(20 mg/1mL)+Neomycin sulfate(3.5 mg/1g)+Octinoxate(7.5 g/100mL)+Oxybenzone(6 g/100mL)+Polymyxin B sulfate(5000 [iU]/1g)+Povidone-iodine(10 mg/1mL)+水(98.6 mL/100mL) Kit Ophthalmic; Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc. 2018-09-13 Not applicable US flag
BEYOND THE SHAVE For Men Octisalate(5 g/100mL)+Allantoin(0.5 g/100mL)+Avobenzone(3.0 g/100mL)+Dimethicone(2.9 g/100mL)+Homosalate(2.5 g/100mL)+Octasulfur(3.0 g/100mL)+Octocrylene(2.7 g / 100毫升) Kit Topical Rodan & Fields 2017-06-01 Not applicable US flag
by Selected Daily Broad Spectrum Sunscreen Octisalate(2.0 g/50mL)+Octinoxate(3.5 g/50mL) Cream Topical Garam Of Nature 2021-07-01 Not applicable US flag
CoreTex Professional Outdoor Skin Protection Wallet Octisalate(5 g/100mL)+ Octisalate(5 g/100g)+ Octisalate(5 g/100mL)+Avobenzone(1 g/100mL)+Avobenzone(1 g/100g)+Avobenzone(3 g/100mL)+Benzocaine(6 g/100mL)+Diphenhydramine hydrochloride(2 g/100mL)+Ethanol(62.5 mL/100mL)+Homosalate(5 g/100mL)+Homosalate(5 g/100g)+Homosalate(7.5 g/100mL)+Octinoxate(7.5 g/100mL)+Octinoxate(7.5 g/100g)+Octocrylene(2.5 g/100mL)+Oxybenzone(6 g/100mL)+Oxybenzone(6 g/100g)+Oxybenzone(6 g/100mL)+Synthetic camphor(0.1 g/100mL)+醋酸锌二水合物(1 g/100mL) Gel; Kit; Lipstick; Liquid; Lotion; Swab Topical CoreTex Products Inc 2019-11-27 Not applicable US flag
CoreTex Professional Outdoor Skin Protection Wallet Octisalate(5 g/100mL)+ Octisalate(5 g/100g)+ Octisalate(5 g/100mL)+Avobenzone(1 g/100mL)+Avobenzone(1 g/100g)+Avobenzone(3 g/100mL)+Benzocaine(6 g/100mL)+Diphenhydramine hydrochloride(2 g/100mL)+Ethanol(62.5 mL/100mL)+Homosalate(5 g/100mL)+Homosalate(5 g/100g)+Homosalate(7.5 g/100mL)+Octinoxate(7.5 g/100mL)+Octinoxate(7.5 g/100g)+Octocrylene(2.5 g/100mL)+Oxybenzone(6 g/100mL)+Oxybenzone(6 g/100g)+Oxybenzone(6 g/100mL)+Synthetic camphor(0.1 g/100mL)+醋酸锌二水合物(1 g/100mL) Gel; Kit; Lipstick; Liquid; Lotion; Swab Topical CoreTex Products Inc 2019-11-27 Not applicable US flag
CoreTex Professional Outdoor Skin Protection Wallet Octisalate(5 g/100mL)+ Octisalate(5 g/100g)+ Octisalate(5 g/100mL)+Avobenzone(1 g/100mL)+Avobenzone(1 g/100g)+Avobenzone(3 g/100mL)+Benzocaine(6 g/100mL)+Diphenhydramine hydrochloride(2 g/100mL)+Ethanol(62.5 mL/100mL)+Homosalate(5 g/100mL)+Homosalate(5 g/100g)+Homosalate(7.5 g/100mL)+Octinoxate(7.5 g/100mL)+Octinoxate(7.5 g/100g)+Octocrylene(2.5 g/100mL)+Oxybenzone(6 g/100mL)+Oxybenzone(6 g/100g)+Oxybenzone(6 g/100mL)+Synthetic camphor(0.1 g/100mL)+醋酸锌二水合物(1 g/100mL) Gel; Kit; Lipstick; Liquid; Lotion; Swab Topical CoreTex Products Inc 2019-11-27 Not applicable US flag
D-one By Tamdoan Bb Light Octisalate(5 g/100g)+Adenosine(0.04 g/100g)+Arbutin(2 g/100g)+Diethylamino hydroxybenzoyl hexyl benzoate(2 g/100g)+Octinoxate(7 g/100g)+Octocrylene(1 g/100g)+Titanium dioxide(2.54 g/100g)+Zinc oxide(5.99 g/100g) Cream Topical Dran Co.,ltd 2016-02-23 2016-09-05 US flag
D-one By Tamdoan Bb Medium Octisalate(5 g/100g)+Adenosine(0.04 g/100g)+Arbutin(2 g/100g)+Diethylamino hydroxybenzoyl hexyl benzoate(2 g/100g)+Octinoxate(7 g/100g)+Octocrylene(1 g/100g)+Titanium dioxide(2.54 g/100g)+Zinc oxide(5.99 g/100g) Cream Topical Dran Co.,ltd 2019-11-19 Not applicable US flag
D-one By Tamdoan Sunscreen 50 Octisalate(5 g/100g)+Adenosine(0.04 g/100g)+Arbutin(2 g/100g)+Diethylamino hydroxybenzoyl hexyl benzoate(2 g/100g)+Octinoxate(7 g/100g)+Octocrylene(1 g/100g)+Titanium dioxide(2.54 g/100g)+Zinc oxide(5.99 g/100g) Cream Topical Dran Co.,ltd 2019-11-19 Not applicable US flag
Dr.althea Aurora Cover Cushion 21 Octisalate(4.8 g/100g)+Adenosine(0.04 g/100g)+Nicotinamide(2 g/100g)+Octinoxate(7 g/100g)+Octocrylene(2 g/100g)+Titanium dioxide(9.00552 g/100g)+Zinc oxide(2 g/100g) Liquid Topical Dr. Althea 2017-04-03 2018-11-22 US flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
  • Humans and other mammals

Chemical Identifiers

UNII
4X49Y0596W
CAS number
118-60-5
InChI Key
FMRHJJZUHUTGKE-UHFFFAOYSA-N
InChI
InChI=1S/C15H22O3/c1-3-5-8-12(4-2)11-18-15(17)13-9-6-7-10-14(13)16/h6-7,9-10,12,16H,3-5,8,11H2,1-2H3
IUPAC Name
2-ethylhexyl 2-hydroxybenzoate
SMILES
CCCCC(CC)COC(=O)C1=C(O)C=CC=C1

References

General References
  1. product info [Link]
  2. MSDS [Link]
Human Metabolome Database
HMDB0061839
PubChem Substance
347911101
ChemSpider
8061
RxNav
91327
ChEBI
88639
ChEMBL
CHEMBL1329203
Wikipedia
Octyl_salicylate

Clinical Trials

Clinical TrialsLearn More" title="" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count
4 Completed Prevention Coronavirus Disease 2019 (COVID‑19)/Sports Nutrition 1
4 Completed Supportive Care Atrophic Vaginitis/Endometrial Hyperplasia/Pelvic Organ Prolapse (POP) 1
4 Completed Supportive Care Skin Irritation 1
4 Completed Treatment Acne Prone Skin 1
4 Completed Treatment Actinic Keratosis (AK) 1
4 Completed Treatment BMI >27 kg/m2/心血管疾病(CVD) 1
4 Completed Treatment 慢性的手Eczema (CHE) 1
4 Completed Treatment Postoperative pain 1
4 Recruiting Treatment Breast Cancer/Vulvo Vaginal Atrophy 1
4 Terminated Not Available Skin Aging 1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Form Route Strength
Kit Ophthalmic; Respiratory (inhalation); Topical
Gel Cutaneous
Powder Topical
Salve Topical
Liquid; spray Topical
Oil Topical
Ointment Topical
Cream; kit; oil; stick Topical
Kit Oral; Topical
Kit; ointment; stick Topical
Cloth; cream Topical
Cream Topical
Jelly Topical
Cream Cutaneous
Lipstick Topical
Gel; kit; lotion Topical
Gel; kit; lipstick; liquid; lotion; swab Topical
Cream; gel; kit; lotion Topical
Kit; stick Topical
Liquid; lotion Topical
Sponge Topical
Kit; lipstick Topical
Cream, augmented Topical
Lotion / shampoo Topical
Paste Topical
Liquid Topical
Solution Topical
Cream; kit Topical
Stick Topical
Cream; kit; lotion Topical
Emulsion Topical
Kit; lotion Topical
Cream; kit; liquid; lotion Topical
Kit; spray Topical
Lotion Cutaneous
Jelly; kit Topical
Aerosol Topical
Spray, suspension Topical
Spray Oral
Kit Topical
Spray Topical
Suspension Topical
Kit; lotion; stick Topical
Lotion Oral
Cloth Topical
Kit; liquid Topical
Lotion; spray Topical
Lotion Topical
Gel Topical
Aerosol, foam Topical
Aerosol, spray Topical
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
预测性能
Property Value Source
水Solubility 0.0238 mg/mL ALOGPS
logP 4.79 ALOGPS
logP 5.35 Chemaxon
logS -4 ALOGPS
pKa (Strongest Acidic) 9.72 Chemaxon
pKa最强(基本) -4.3 Chemaxon
Physiological Charge 0 Chemaxon
Hydrogen Acceptor Count 2 Chemaxon
Hydrogen Donor Count 1 Chemaxon
Polar Surface Area 46.53 Å2 Chemaxon
Rotatable Bond Count 8 Chemaxon
Refractivity 72.21 m3·mol-1 Chemaxon
Polarizability 28.8 Å3 Chemaxon
Number of Rings 1 Chemaxon
Bioavailability 1 Chemaxon
Rule of Five No Chemaxon
Ghose Filter Yes Chemaxon
Veber's Rule No Chemaxon
MDDR-like Rule No Chemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Spectrum Spectrum Type Splash Key
GC-MS Spectrum - EI-B GC-MS splash10-00di-9800000000-e6bf91bd63e14169eb92
Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available

Drug created at December 03, 2015 16:51 / Updated at February 21, 2021 18:52