微粒体谷胱甘肽S-transferase 3

Details

Name
微粒体谷胱甘肽S-transferase 3
Synonyms
  • 2.5.1.18
  • Microsomal GST-3
  • Microsomal GST-III
Gene Name
MGST3
Organism
Humans
Amino acid sequence
>lcl|BSEQ0011641|Microsomal glutathione S-transferase 3 MAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRA HQNTLEVYPPFLFFLAVGGVYHPRIASGLGLAWIVGRVLYAYGYYTGEPSKRSRGALGSI ALLGLVGTTVCSAFQHLGWVKSGLGSGPKCCH
Number of residues
152
Molecular Weight
16516.185
Theoretical pI
9.68
GO Classification
Functions
glutathione peroxidase activity/glutathione transferase activity/peroxidase activity
Processes
glutathione derivative biosynthetic process/lipid metabolic process/response to organonitrogen compound/signal transduction/small molecule metabolic process/xenobiotic metabolic process
Components
endoplasmic reticulum membrane/extracellular exosome/integral component of membrane/intracellular membrane-bounded organelle/membrane/nuclear envelope
General Function
Peroxidase activity
Specific Function
Also functions as a glutathione peroxidase.
Pfam Domain Function
Transmembrane Regions
9-29 71-91 120-140
Cellular Location
Endoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0011642|Microsomal glutathione S-transferase 3 (MGST3) ATGGCTGTCCTCTCTAAGGAATATGGTTTTGTGCTTCTAACTGGTGCTGCCAGCTTTATA ATGGTGGCCCACCTAGCCATCAATGTTTCCAAGGCCCGCAAGAAGTACAAAGTGGAGTAT CCTATCATGTACAGCACGGACCCTGAAAATGGGCACATCTTCAACTGCATTCAGCGAGCC CACCAGAACACGTTGGAAGTGTATCCTCCCTTCTTATTTTTTCTAGCTGTTGGAGGTGTT TACCACCCGCGTATAGCTTCTGGCCTGGGCTTGGCCTGGATTGTTGGACGAGTTCTTTAT GCTTATGGCTATTACACGGGAGAACCCAGCAAGCGTAGTCGAGGAGCCCTGGGGTCCATC GCCCTCCTGGGCTTGGTGGGCACAACTGTGTGCTCTGCTTTCCAGCATCTTGGTTGGGTT AAAAGTGGCTTGGGCAGTGGACCCAAATGCTGCCATTAA
Chromosome Location
1
Locus
1q23
External Identifiers
Resource Link
UniProtKB ID O14880
UniProtKB Entry Name MGST3_HUMAN
GenBank Protein ID 2583081
GenBank Gene ID AF026977
GenAtlas ID MGST3
HGNC ID HGNC:7064
General References
  1. Jakobsson PJ, Mancini JA, Riendeau D, Ford-Hutchinson AW: Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities. J Biol Chem. 1997 Sep 5;272(36):22934-9. [Article]
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Drug Relations

Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details
DB00143 Glutathione approved, investigational, nutraceutical unknown Details