Vascular endothelial growth factor A

Details

Name
Vascular endothelial growth factor A
年代ynonyms
  • Vascular permeability factor
  • VEGF
  • VEGF-A
  • VPF
Gene Name
VEGFA
Organism
Humans
Amino acid sequence
>拼箱| BSEQ0000325 |血管内皮生长的r A MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVD IFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEM SFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPG PHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
Number of residues
232
分子量
27042.205
Theoretical pI
9.08
GO Classification
Functions
chemoattractant activity/cytokine activity/extracellular matrix binding/fibronectin binding/growth factor activity/heparin binding/identical protein binding/neuropilin binding/platelet-derived growth factor receptor binding/protein heterodimerization activity/protein homodimerization activity/receptor agonist activity/vascular endothelial growth factor receptor 1 binding/vascular endothelial growth factor receptor 2 binding/vascular endothelial growth factor receptor binding
Processes
activation of protein kinase activity/angiogenesis/artery morphogenesis/basophil chemotaxis/blood coagulation/branching morphogenesis of an epithelial tube/camera-type eye morphogenesis/cardiac muscle fiber development/cardiac vascular smooth muscle cell development/cell maturation/cell migration involved in sprouting angiogenesis/cellular response to hypoxia/cellular response to vascular endothelial growth factor stimulus/commissural neuron axon guidance/coronary artery morphogenesis/冠状vein morphogenesis/dopaminergic neuron differentiation/endothelial cell chemotaxis/epithelial cell differentiation/eye photoreceptor cell development/growth/heart morphogenesis/in utero embryonic development/induction of positive chemotaxis/kidney development/lactation/lung development/lymph vessel morphogenesis/macrophage differentiation/mammary gland alveolus development/mesoderm development/monocyte differentiation/negative regulation of apoptotic process/negative regulation of cysteine-type endopeptidase activity involved in apoptotic process/negative regulation of transcription from RNA polymerase II promoter/nervous system development/outflow tract morphogenesis/ovarian follicle development/patterning of blood vessels/platelet activation/platelet degranulation/positive chemotaxis/positive regulation of angiogenesis/positive regulation of axon extension involved in axon guidance/positive regulation of blood vessel endothelial cell migration/positive regulation of branching involved in ureteric bud morphogenesis/positive regulation of cell adhesion/positive regulation of cell division/positive regulation of cell migration/positive regulation of cell migration involved in sprouting angiogenesis/positive regulation of cell proliferation/positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway/positive regulation of cellular component movement/positive regulation of CREB transcription factor activity/positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway/positive regulation of endothelial cell migration/positive regulation of endothelial cell proliferation/positive regulation of epithelial cell proliferation/positive regulation of ERK1 and ERK2 cascade/positive regulation of focal adhesion assembly/positive regulation of gene expression/positive regulation of histone deacetylase activity/positive regulation of leukocyte migration/positive regulation of MAP kinase activity/positive regulation of mast cell chemotaxis/positive regulation of mesenchymal cell proliferation/positive regulation of neuroblast proliferation/positive regulation of p38MAPK cascade/positive regulation of peptidyl-serine phosphorylation/positive regulation of peptidyl-tyrosine autophosphorylation/positive regulation of peptidyl-tyrosine phosphorylation/positive regulation of positive chemotaxis/积极调控的蛋白质n autophosphorylation/积极调控的蛋白质n complex assembly/积极调控的蛋白质n kinase C signaling/积极调控的蛋白质n kinase D signaling/积极调控的蛋白质n localization to early endosome/积极调控的蛋白质n phosphorylation/positive regulation of receptor internalization/positive regulation of retinal ganglion cell axon guidance/positive regulation of transcription from RNA polymerase II promoter/positive regulation of transcription from RNA polymerase II promoter in response to hypoxia/positive regulation of vascular endothelial growth factor receptor signaling pathway/positive regulation of vascular permeability/post-embryonic camera-type eye development/primitive erythrocyte differentiation/regulation of cell shape/regulation of cGMP metabolic process/regulation of retinal ganglion cell axon guidance/regulation of transcription from RNA polymerase II promoter/regulation of transcription from RNA polymerase II promoter in response to hypoxia/response to hypoxia/surfactant homeostasis/tube formation/vascular endothelial growth factor receptor signaling pathway/vascular endothelial growth factor signaling pathway/vasculogenesis/VEGF-activated neuropilin signaling pathway
Components
cell surface/cytoplasm/extracellular region/extracellular space/membrane/platelet alpha granule lumen/proteinaceous extracellular matrix/secretory granule
General Function
Vascular endothelial growth factor receptor binding
年代pecific Function
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
年代ecreted
Gene sequence
>lcl|BSEQ0021644|Vascular endothelial growth factor A (VEGFA) CTGACGGACAGACAGACAGACACCGCCCCCAGCCCCAGCTACCACCTCCTCCCCGGCCGG CGGCGGACAGTGGACGCGGCGGCGAGCCGCGGGCAGGGGCCGGAGCCCGCGCCCGGAGGC GGGGTGGAGGGGGTCGGGGCTCGCGGCGTCGCACTGAAACTTTTCGTCCAACTTCTGGGC TGTTCTCGCTTCGGAGGAGCCGTGGTCCGCGCGGGGGAAGCCGAGCCGAGCGGAGCCGCG AGAAGTGCTAGCTCGGGCCGGGAGGAGCCGCAGCCGGAGGAGGGGGAGGAGGAAGAAGAG AAGGAAGAGGAGAGGGGGCCGCAGTGGCGACTCGGCGCTCGGAAGCCGGGCTCATGGACG GGTGAGGCGGCGGTGTGCGCAGACAGTGCTCCAGCCGCGCGCGCTCCCCAGGCCCTGGCC CGGGCCTCGGGCCGGGGAGGAAGAGTAGCTCGCCGAGGCGCCGAGGAGAGCGGGCCGCCC CACAGCCCGAGCCGGAGAGGGAGCGCGAGCCGCGCCGGCCCCGGTCGGGCCTCCGAAACC ATGAACTTTCTGCTGTCTTGGGTGCATTGGAGCCTTGCCTTGCTGCTCTACCTCCACCAT GCCAAGTGGTCCCAGGCTGCACCCATGGCAGAAGGAGGAGGGCAGAATCATCACGAAGTG GTGAAGTTCATGGATGTCTATCAGCGCAGCTACTGCCATCCAATCGAGACCCTGGTGGAC ATCTTCCAGGAGTACCCTGATGAGATCGAGTACATCTTCAAGCCATCCTGTGTGCCCCTG ATGCGATGCGGGGGCTGCTGCAATGACGAGGGCCTGGAGTGTGTGCCCACTGAGGAGTCC AACATCACCATGCAGATTATGCGGATCAAACCTCACCAAGGCCAGCACATAGGAGAGATG AGCTTCCTACAGCACAACAAATGTGAATGCAGACCAAAGAAAGATAGAGCAAGACAAGAA AAAAAATCAGTTCGAGGAAAGGGAAAGGGGCAAAAACGAAAGCGCAAGAAATCCCGGTAT AAGTCCTGGAGCGTGTACGTTGGTGCCCGCTGCTGTCTAATGCCCTGGAGCCTCCCTGGC CCCCATCCCTGTGGGCCTTGCTCAGAGCGGAGAAAGCATTTGTTTGTACAAGATCCGCAG ACGTGTAAATGTTCCTGCAAAAACACAGACTCGCGTTGCAAGGCGAGGCAGCTTGAGTTA AACGAACGTACTTGCAGATGTGACAAGCCGAGGCGGTGA
Chromosome Location
6
Locus
6p12
External Identifiers
Resource Link
UniProtKB ID P15692
UniProtKB条目名称 VEGFA_HUMAN
GenBank Protein ID 181971
GenBank Gene ID M32977
GenAtlas ID VEGF
HGNC ID HGNC:12680
General References
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Drug Relations

Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details
DB01270 Ranibizumab approved yes antibody Details
DB01017 Minocycline approved, investigational unknown inhibitor Details
DB01120 Gliclazide approved unknown other/unknown Details
DB01136 Carvedilol approved, investigational unknown other Details
DB03088 Pidolic acid approved, investigational unknown Details
DB00112 Bevacizumab approved, investigational yes Details
DB04895 Pegaptanib approved, investigational yes antagonist Details
DB05294 Vandetanib approved unknown inhibitor Details
DB05434 ABT-510 investigational unknown Details
DB05890 Veglin investigational unknown Details
DB05932 Denibulin investigational unknown Details
DB05969 年代NS-032 investigational unknown Details
DB06642 Bevasiranib investigational unknown Details
DB06779 Dalteparin approved yes inhibitor Details
DB08885 Aflibercept approved yes binder Details
DB09301 Chondroitin sulfate approved, investigational, nutraceutical unknown Details
DB10772 包皮角化细胞(neonatal) approved yes agonist Details
DB14864 Brolucizumab approved, investigational yes inhibitor Details
DB15303 Faricimab approved, investigational yes antagonist Details
DB12317 Vanucizumab investigational unknown regulator Details