Heterogeneous nuclear ribonucleoprotein D0

Details

Name
Heterogeneous nuclear ribonucleoprotein D0
Synonyms
  • AU-rich element RNA-binding protein 1
  • AUF1
  • hnRNP D0
  • HNRPD
Gene Name
HNRNPD
Organism
Humans
Amino acid sequence
>lcl|BSEQ0049909|Heterogeneous nuclear ribonucleoprotein D0 MSEEQFGGDGAAAAATAAVGGSAGEQEGAMVAATQGAAAAAGSGAGTGGGTASGGTEGGS AESEGAKIDASKNEEDEGHSNSSPRHSEAATAQREEWKMFIGGLSWDTTKKDLKDYFSKF GEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEHKLNGKVIDPKRAKAMKTKEP VKKIFVGGLSPDTPEEKIREYFGGFGEVESIELPMDNKTNKRRGFCFITFKEEEPVKKIM EKKYHNVGLSKCEIKVAMSKEQYQQQQQWGSRGGFAGRARGRGGGPSQNWNQGYSNYWNQ GYGNYGYNSQGYGGYGGYDYTGYNNYYGYGDYSNQQSGYGKVSRRGGHQNSYKPY
Number of residues
355
分子量
38434.09
Theoretical pI
Not Available
GO Classification
Functions
AT DNA binding/chromatin binding/histone deacetylase binding/mRNA 3'-UTR AU-rich region binding/RNA binding/telomeric DNA binding/transcription factor binding
Processes
3'-UTR-mediated mRNA destabilization/cellular response to amino acid stimulus/cellular response to estradiol stimulus/cellular response to nitric oxide/cellular response to putrescine/cerebellum development/circadian regulation of translation/gene expression/hepatocyte dedifferentiation/liver development/mRNA splicing, via spliceosome/mRNA stabilization/mRNA transcription from RNA polymerase II promoter/积极regulation of gene expression/积极regulation of telomerase RNA reverse transcriptase activity/积极regulation of telomere capping/积极regulation of transcription, DNA-templated/积极regulation of translation/regulation of circadian rhythm/regulation of mRNA stability/regulation of telomere maintenance/regulation of transcription, DNA-templated/response to calcium ion/response to drug/response to electrical stimulus/response to rapamycin/response to sodium phosphate/RNA catabolic process/RNA processing/transcription, DNA-templated
Components
cytosol/extracellular exosome/intracellular ribonucleoprotein complex/nucleoplasm/nucleus
General Function
Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation.
Specific Function
At dna binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
核ribonucleop >拼箱| BSEQ0049910 |异构rotein D0 (HNRNPD) ATGTCGGAGGAGCAGTTCGGCGGGGACGGGGCGGCGGCAGCGGCAACGGCGGCGGTAGGC GGCTCGGCGGGCGAGCAGGAGGGAGCCATGGTGGCGGCGACACAGGGGGCAGCGGCGGCG GCGGGAAGCGGAGCCGGGACCGGGGGCGGAACCGCGTCTGGAGGCACCGAAGGGGGCAGC GCCGAGTCGGAGGGGGCGAAGATTGACGCCAGTAAGAACGAGGAGGATGAAGGCCATTCA AACTCCTCCCCACGACACTCTGAAGCAGCGACGGCACAGCGGGAAGAATGGAAAATGTTT ATAGGAGGCCTTAGCTGGGACACTACAAAGAAAGATCTGAAGGACTACTTTTCCAAATTT GGTGAAGTTGTAGACTGCACTCTGAAGTTAGATCCTATCACAGGGCGATCAAGGGGTTTT GGCTTTGTGCTATTTAAAGAATCGGAGAGTGTAGATAAGGTCATGGATCAAAAAGAACAT AAATTGAATGGGAAGGTGATTGATCCTAAAAGGGCCAAAGCCATGAAAACAAAAGAGCCG GTTAAAAAAATTTTTGTTGGTGGCCTTTCTCCAGATACACCTGAAGAGAAAATAAGGGAG TACTTTGGTGGTTTTGGTGAGGTGGAATCCATAGAGCTCCCCATGGACAACAAGACCAAT AAGAGGCGTGGGTTCTGCTTTATTACCTTTAAGGAAGAAGAACCAGTGAAGAAGATAATG GAAAAGAAATACCACAATGTTGGTCTTAGTAAATGTGAAATAAAAGTAGCCATGTCGAAG GAACAATATCAGCAACAGCAACAGTGGGGATCTAGAGGAGGATTTGCAGGAAGAGCTCGT GGAAGAGGTGGTGGCCCCAGTCAAAACTGGAACCAGGGATATAGTAACTATTGGAATCAA GGCTATGGCAACTATGGATATAACAGCCAAGGTTACGGTGGTTATGGAGGATATGACTAC ACTGGTTACAACAACTACTATGGATATGGTGATTATAGCAACCAGCAGAGTGGTTATGGG AAGGTATCCAGGCGAGGTGGTCATCAAAATAGCTACAAACCATACTAA
Chromosome Location
4
Locus
4q21.22
External Identifiers
Resource Link
UniProtKB ID Q14103
UniProtKB Entry Name HNRPD_HUMAN
HGNC ID HGNC:5036
一般引用
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Drug Relations

Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details
DB11638 Artenimol approved, experimental, investigational unknown ligand Details