Zinc transporter 3
Details
- Name
- Zinc transporter 3
- Synonyms
-
- Solute carrier family 30 member 3
- ZnT-3
- ZNT3
- Gene Name
- SLC30A3
- Organism
- Humans
- Amino acid sequence
-
>lcl|BSEQ0052353|Zinc transporter 3 MEPSPAAGGLETTRLVSPRDRGGAGGSLRLKSLFTEPSEPLPEESKPVEMPFHHCHRDPL PPPGLTPERLHARRQLYAACAVCFVFMAGEVVGGYLAHSLAIMTDAAHLLADVGSMMGSL FSLWLSTRPATRTMTFGWHRSETLGALASVVSLWMVTGILLYLAFVRLLHSDYHIEGGAM LLTASIAVCANLLMAFVLHQAGPPHSHGSRGAEYAPLEEGPEEPLPLGNTSVRAAFVHVL GDLLQSFGVLAASILIYFKPQYKAADPISTFLFSICALGSTAPTLRDVLRILMEGTPRNV GFEPVRDTLLSVPGVRATHELHLWALTLTYHVASAHLAIDSTADPEAVLAEASSRLYSRF GFSSCTLQVEQYQPEMAQCLRCQEPPQA
- Number of residues
- 388
- 分子量
- 41944.895
- Theoretical pI
- Not Available
- GO Classification
-
FunctionsATPase-coupled zinc transmembrane transporter activity/zinc ion transmembrane transporter activityProcessespositive regulation of transport/regulation of sequestering of zinc ion/response to zinc ion/zinc ion import into synaptic vesicle/zinc ion transmembrane transportComponentscell junction/cytoplasm/endosome/glutamatergic synapse/hippocampal mossy fiber to CA3 synapse/integral component of plasma membrane/integral component of synaptic vesicle membrane/late endosome/late endosome membrane/lysosomal membrane/membrane/neuron projection/plasma membrane/synaptic vesicle
- General Function
- Involved in accumulation of zinc in synaptic vesicles.
- Specific Function
- Atpase-coupled zinc transmembrane transporter activity
- Pfam Domain Function
-
- Cation_efflux (PF01545)
- Transmembrane Regions
- 76-96 106-126 146-166 178-198 236-256 265-285
- Cellular Location
- Cytoplasmic vesicle
- Gene sequence
-
>lcl|BSEQ0052354|Zinc transporter 3 (SLC30A3) ATGGAGCCCTCTCCAGCCGCTGGGGGCTTGGAGACCACTCGCCTGGTGAGCCCCCGGGAC CGCGGTGGCGCCGGAGGCAGCCTGCGTTTGAAGAGTCTCTTCACAGAGCCCTCAGAGCCC CTCCCTGAGGAGTCCAAACCTGTGGAGATGCCCTTCCACCACTGCCACAGGGACCCCCTT CCGCCGCCGGGCCTTACCCCTGAGAGGCTGCATGCACGGAGGCAGCTATATGCTGCCTGT GCCGTTTGCTTTGTCTTCATGGCTGGGGAGGTGGTCGGCGGGTATCTGGCACACAGCCTG GCCATCATGACCGATGCAGCCCACTTGCTGGCGGATGTGGGCAGCATGATGGGCAGCCTC TTCTCCCTCTGGCTCTCCACCCGTCCAGCCACCCGCACCATGACCTTTGGCTGGCACCGT TCAGAGACTCTGGGGGCTTTGGCCTCTGTGGTCTCCCTCTGGATGGTCACTGGCATCCTC CTGTACCTGGCCTTCGTCCGCCTGCTGCACAGCGACTACCACATCGAGGGGGGTGCCATG CTGCTGACCGCCAGCATCGCAGTCTGTGCCAACCTGTTAATGGCCTTTGTGCTGCACCAG GCTGGGCCCCCCCACAGCCACGGGTCTAGGGGAGCAGAGTATGCACCGCTGGAGGAGGGG CCTGAAGAGCCCCTGCCCCTGGGGAACACCAGCGTCCGGGCGGCATTTGTGCACGTGCTG GGGGACCTCCTGCAGAGCTTTGGGGTACTGGCTGCCTCCATCCTCATCTACTTCAAGCCT CAATACAAGGCAGCCGACCCCATCAGCACCTTCCTCTTCTCCATCTGTGCCCTTGGATCC ACCGCTCCCACCCTCCGAGACGTTCTTCGAATCCTCATGGAAGGTACCCCCCGCAATGTG GGGTTCGAACCTGTGCGGGATACGCTGTTGTCGGTGCCAGGAGTCCGGGCAACCCATGAG CTGCACCTGTGGGCCCTTACGCTCACTTACCATGTTGCCTCTGCACACCTGGCCATCGAC TCCACCGCTGACCCTGAAGCCGTCCTGGCTGAAGCCTCATCCCGGCTCTACTCCCGGTTT GGATTCTCCAGCTGCACCCTGCAGGTCGAGCAGTATCAGCCGGAGATGGCCCAGTGCCTG CGCTGCCAGGAACCCCCCCAAGCCTGA
- Chromosome Location
- 2
- Locus
- 2p23.3
- External Identifiers
-
Resource Link UniProtKB ID Q99726 UniProtKB Entry Name ZNT3_HUMAN HGNC ID HGNC: 11014 - General References
-
- Palmiter RD, Cole TB, Quaife CJ, Findley SD: ZnT-3, a putative transporter of zinc into synaptic vesicles. Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14934-9. doi: 10.1073/pnas.93.25.14934. [Article]
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- Falcon-Perez JM, Dell'Angelica EC: Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes. Exp Cell Res. 2007 Apr 15;313(7):1473-83. doi: 10.1016/j.yexcr.2007.02.006. Epub 2007 Feb 15. [Article]
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